Programmes > Par auteur > Bennett E. Andrew

7000 Years of the Human Oral Microbiome in France
E. Andrew Bennett  1@  , Samantha Brunel  1@  , Olivier Gorgé  1@  , Eva-Maria Geigl  1@  , Thierry Grange  1@  , Mélanie Pruvost  1@  
1 : Institut Jacques Monod  (IJM)  -  Site web
Université Paris Diderot - Paris 7, Centre National de la Recherche Scientifique : UMR7592
Université Paris Diderot, Bât. Buffon, 15 rue Hélène Brion, 75205 Paris cédex 13 -  France

The study of ancient microbial DNA recovered from the dental calculus of human remains permits an unprecedented view into the prehistoric origins of the modern human oral microbiome. Several studies have attempted to describe the impact changing dietary and hygiene practices have had on our oral microbiota over time, as well as begun to retrace the evolution of oral pathogens.

In order to better understand to what extent our oral microbiomes can enlighten us to the behavior of past populations, as well as to follow the regional appearance and coevolution of commensual and pathogenic oral microbes, we have mapped out the oral microbial landscapes of several distinct geographical regions of France over a period spanning 7000 years, from the Neolithic to the Middle Ages and beyond. We have performed high throughput shotgun sequencing of dental calculus from over 300 individuals, and use these data to see what can be learned about past human communities through their oral microbiome and human oral microbial evolution, and to comparatively explore the complexity of our changing oral microbiome across individuals, populations, geography and time.

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